EFFECT OF PHENOBARBITAL ON HEPATIC CYP1A1 AND CYP1A2 IN THE AHR-NULL MOUSE

Authors
ZAHER H YANG TJ GELBOIN HV FERNANDEZSALGUERO P GONZALEZ FJ
Citation
H. Zaher et al., EFFECT OF PHENOBARBITAL ON HEPATIC CYP1A1 AND CYP1A2 IN THE AHR-NULL MOUSE, Biochemical pharmacology, 55(2), 1998, pp. 235-238
Citations number
25
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
Biochemical pharmacology → ACNP
ISSN journal
00062952
Volume
55
Issue
2
Year of publication
1998
Pages
235 - 238
Database
ISI
SICI code
0006-2952(1998)55:2<235:EOPOHC>2.0.ZU;2-D
Abstract
Studies have suggested that phenobarbital (PB) induces members of the CYP1A subfamily by both transcriptional and post-transcriptional mecha nisms. Using the Ahr-/- mice, we examined the induction of CYP1A1 and CYP1A2 by PB. CYP1A2 mRNA and protein were induced by PB in the null m ice, suggesting that CYP1A2 is regulated by PB by a mechanism independ ent of the aryl hydrocarbon receptor (AHR). In contrast, the regulatio n oi CYP1A1 is highly dependent on the AHR. (C) 1998 Elsevier Science Inc.