We discuss several implications of R-4 couplings in M-theory when comp
actified on Calabi-Yau (CY) manifolds. In particular, these couplings
can be predicted by supersymmetry from the mixed gauge-gravitational C
hem-Simons couplings in five dimensions and are related to the one-loo
p holomorphic anomaly in four-dimensional N = 2 theories, We find a ne
w contribution to the Einstein term in five dimensions proportional to
the Euler number of the internal CY threefold, which corresponds to a
one-loop correction of the hypermultiplet geometry, This correction i
s reproduced by a direct computation in type II string theories, Final
ly, we discuss a universal non-perturbative correction to the type IIB
hyper-metric. (C) 1997 Elsevier Science B.V.