CLINICAL AND MICROBIOLOGICAL EFFECTS OF MINOCYCLINE-LOADED MICROCAPSULES IN ADULT PERIODONTITIS

CLINICAL AND MICROBIOLOGICAL EFFECTS of subgingival delivery of 10% mi nocycline-loaded (MC), bioabsorbable microcapsules were examined in 15 adult periodontitis patients. Patients received oral hygiene instruct ion 2 weeks prior to the study. At baseline (day 0) all teeth received supragingival scaling (SC); 2 quadrants received no further treatment and 1 quadrant received subgingival scaling and root planing (SRP). I n the fourth quadrant, the tooth with the deepest probing sites (at le ast 1 site greater than or equal to 5 mm) was treated with minocycline microcapsules. The sites were evaluated at baseline and weeks 1, 2, 4 , and 6. Clinical indices included breeding on probing (BOP), probing depths (PD), and attachment lass (AL). Microbiological evaluations inc luded percent morphotypes by phase-contrast microscopy; cultivable ana erobic, aerobic, and black-pigmented Bacteroides (BPB); and percent Po rphyromonas gingivalis, Prevotella intermedia, Eikenella corrodens, an d Actinomyces viscosus by indirect immunofluorescence, In the SC+MC gr oup, BOP, PD, and AL were significantly reduced from baseline for week s 1 to 6. BOP in the SC+MC group was significantly reduced compared to the SRP group from weeks 2 to 6. In the SC+MC group the percent of sp irochetes and motile rods decreased and the percent of cocci increased after 1 week, The increased cocci and decreased motile rods were stat istically greater at weeks 4 and 6 in the SC+MC group compared to the SRP group. This study demonstrates that local subgingival delivery of 10% minocycline-loaded microcapsules as an adjunct to scaling results in reduction in the percent sites breeding on probing greater than sca ling and root planing alone and induces a microbial response more favo rable Tor periodontal health than scaling and root planing.