NONSYMMETRICALLY SUBSTITUTED CYCLIC UREA HIV PROTEASE INHIBITORS

Authors
WILKERSON WW DAX S CHEATHAM WW
Citation
Ww. Wilkerson et al., NONSYMMETRICALLY SUBSTITUTED CYCLIC UREA HIV PROTEASE INHIBITORS, Journal of medicinal chemistry, 40(25), 1997, pp. 4079-4088
Citations number
19
Journal title
Journal of medicinal chemistry → ACNP
ISSN journal
00222623
Volume
40
Issue
25
Year of publication
1997
Pages
4079 - 4088
Database
ISI
SICI code
0022-2623(1997)40:25<4079:NSCUHP>2.0.ZU;2-B
Abstract
A series of nonsymmetrically substituted cyclic ureacarboxamides was s ynthesized and evaluated for antiviral activity as a function of the i nhibition of HIV-protease. Selected protease inhibitors were also eval uated for oral bioavailability. The synthesis, pharmacology, quantitat ive structure-activity relationship (QSAR), and pharmacokinetics for t he series will be discussed.