Objective: The purpose of this study is to determine the efficacy of i
nitial trabeculotomy in the patient with aniridic glaucoma. Design: Cl
inical charts were reviewed. Participants: Twenty-nine eyes of 16 pati
ents with aniridia were studied. Intervention: Glaucoma surgery was pe
rformed. As an initial procedure, trabeculotomy was performed in 12 ey
es, other surgery was performed in 17 eyes (trabeculectomy, 5; gonioto
my, 5; other, 7). Main Outcome Measures: Success was defined as an int
raocular pressure (IOP) of 21 mmHg or lower, and no further surgery wa
s performed. Results: Ten (83%) of 12 eyes obtained IOP control after
first (6 eyes) or second (4 eyes) trabeculotomy with a mean follow-up
period of 9.5 years, Five eyes maintained visual acuity of 20/40 to 20
/200, No serious complications were found after trabeculotomy. Three (
18%) of 17 eyes were controlled with the first glaucoma surgery other
than trabeculotomy (goniotomy, trabeculectomy, trabeculectomy combined
with trabeculotomy, and Molteno implant). Good IOP control was obtain
ed in 8 (47%) of 17 eyes after several surgeries with a mean follow-up
period of 10.4 years. Four of 17 eyes became phthisical. Conclusion:
This study suggests that trabeculotomy is the preferred initial operat
ion for uncontrolled glaucoma with aniridia.