LINEAR GROWTH-CHARACTERISTICS OF CHILDREN WITH CLEFT-LIP AND PALATE

Objective: To study the linear growth characteristics of children with isolated cleft lip (CL), cleft palate (CP), or both (CLP) and to dete rmine whether this population is at risk for short stature. Study desi gn: Retrospective chart review identified 324 patients with CL, CP, or CLP that displayed no additional congenital anomalies. Longitudinal h eight and growth rate analyses were performed on routine anthropometri c measurements gathered from hospital and clinic records. One-sample t tests (p < 0.05) of average height percentiles were performed at year ly intervals. Analysis of variance was performed on clefting subgroups . Results: From birth to 10 years of age, the average height of both m ale and female white patients is consistently near the 40th percentile . At yearly intervals, 60% of male and 70% of female average heights d emonstrate statistical difference from the population mean. For all pa tients, 64% of male but only 36% of female growth rates, from 2.5 to 1 2 years of age, were above the population mean. Conclusions: White chi ldren from birth to 10 years of age with isolated CL, CP, or CLP demon strated a mean height below the population mean. These data suggest th at children with isolated clefting manifest an intrinsic tendency-towa rd short stature. In addition, male patients display above-average gro wth rates, whereas female patients display below-average growth rates, from 2 to 18 years of age. The data imply that female patients may be at increased risk of overall short stature, whereas male patients may eventually obtain mean population height.