DIFFERENCE BETWEEN LAMBS WITH CHRONIC AND MILD DERMATOPHILOSIS IN FREQUENCY OF ALLELES OF CD3-GAMMA

Southern blots prepared with DNA from 20 Merino lambs that previously had chronic dermatophilosis (chronic) and ?20 lambs that previously ha d mild dermatophilosis lesions (resistant) were hybridised with DNA se quences of the genes for the T-cell receptor-beta (TCR beta), a TCR-as sociated peptide 'cluster designation 3 gamma chain' (CD3 gamma) and o vine Major Histocompatibility Complex class 1 (ov. MHC class 1). There was a significant difference in the incidence of an allele of CD3 gam ma between the chronic and resistant lambs. No significant difference in the incidence of alleles of TCR beta or ov. MHC class 1 was detecte d. (C) 1997 Elsevier Science B.V.