INFLUENCE OF CIPROFLOXACIN ON PHARMACOKINETICS OF RIFAMPIN

Authors
JHAJ R ROY A UPPAL R BEHERA D
Citation
R. Jhaj et al., INFLUENCE OF CIPROFLOXACIN ON PHARMACOKINETICS OF RIFAMPIN, Current therapeutic research, 58(4), 1997, pp. 260-265
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy","Medicine, Research & Experimental
Journal title
Current therapeutic research → ACNP
ISSN journal
0011393X
Volume
58
Issue
4
Year of publication
1997
Pages
260 - 265
Database
ISI
SICI code
0011-393X(1997)58:4<260:IOCOPO>2.0.ZU;2-W
Abstract
The pharmacokinetics of oral rifampin was studied in rabbits (24 mg/kg per day) as well as in humans (450 mg/d) who were taking antitubercul osis medicine, after concurrent ciprofloxacin administration for a min imum of 5 days. There were no significant changes in the maximum plasm a concentration (C-max), time at C-max, area under the plasma concentr ation-time curve, or elimination half-life of rifampin after ciproflox acin coadministration in rabbits or humans.