DE-NOVO AML WITH TRILINEAGE MYELODYSPLASIA AND A NOVEL T(11-12)(P15-Q13)

De novo acute myeloid leukemia with trilineage myelodysplasia (AML/TMD S) is an uncommon form of leukemia characterized by a dyshematopoietic picture accompanying the acute leukemia, a poor response to induction chemotherapy, and a tendency to relapse with pure myelodysplastic syn drome. Cytogenetic information on this entity is scarce, although some cases have been reported to be associated with t(7;11)(p15;p15). A 41 -year-old woman who had a history of radiotherapy for breast cancer pr esented with AML/TMDS and was found to have a unique t(11;12)(p15;q13) abnormality. (C) Elsevier Science Inc., 1998.