SEVERE APLASTIC-ANEMIA IN ASSOCIATION WITH A UNIQUE CONSTITUTIONAL TRANSLOCATION 46,XY,T(6-10)(Q13-Q22)C

Authors
HUDSON J CHOWN S LAWLER M DUGGAN C TEMPERLEY IJ SECKERWALKER L
Citation
J. Hudson et al., SEVERE APLASTIC-ANEMIA IN ASSOCIATION WITH A UNIQUE CONSTITUTIONAL TRANSLOCATION 46,XY,T(6-10)(Q13-Q22)C, British Journal of Haematology, 99(3), 1997, pp. 520-521
Citations number
9
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
99
Issue
3
Year of publication
1997
Pages
520 - 521
Database
ISI
SICI code
0007-1048(1997)99:3<520:SAIAWA>2.0.ZU;2-4
Abstract
Severe aplastic anaemia (SAA) is an uncommon disorder which may be ass ociated with several congenital syndromes. However, it has rarely been described in association with a constitutional karyotypic abnormality , The breakpoint of the balanced t(6;10)(q13:q22) translocation descri bed here does not disrupt any currently recognized gene of haemopoieti c or stromal importance. This report also highlights the problems inhe rent in the use of bone marrow transplantation (BMT) for treating mult iply transfused aplastic anaemia patients.