K. Petitprez et al., MOLECULAR-CLONING AND EXPRESSION OF AN ANTIIDIOTYPE ANTIBODY MIMICKING A PROTECTIVE OLIGOSACCHARIDE OF THE PARASITE SCHISTOSOMA-MANSONI, Parasitology research, 84(1), 1998, pp. 38-40
Genes encoding the heavy and light chains of an anti-idiotype antibody
(AB2) mimicking a protective oligosaccharide of Schistosoma mansoni w
ere cloned and expressed as a single-chain Fv fragment. The expression
in a functional state was tested using the AB1. A specific binding be
tween sFv and AB1 was observed. Immunization with the recombinant AB2
indicates its capacity to elicit anti-S. mansoni antibodies.