A new neoclerodane diterpenoid, (13R)-6 alpha,11 beta-diacetoxy-1 beta
,12 alpha-diisobutyryloxy-4 alpha,18;8 beta,13-diepoxy-neo-clerodan-15
,16-olide (Scuteguatemalin) has been isolated from the aerial parts of
Scutellaria guatemalensis besides the known skullcapflavone II. The s
tructure of the new diterpenoid was established by spectroscopic metho
ds and confirmed by X-Ray analysis.