PROGNOSTIC FACTORS IN OLIGODENDROGLIOMA

Citation
D. Schiffer et al., PROGNOSTIC FACTORS IN OLIGODENDROGLIOMA, Canadian journal of neurological sciences, 24(4), 1997, pp. 313-319
Citations number
48
ISSN journal
03171671
Volume
24
Issue
4
Year of publication
1997
Pages
313 - 319
Database
ISI
SICI code
0317-1671(1997)24:4<313:PFIO>2.0.ZU;2-L
Abstract
Background: A reliable marker for tumor oligodendroglial cells is not yet available, so that the histological recognition of the tumor still encounters uncertainties. There is no general agreement also on progn ostic factors in oligodendroglioma. The inconsistency concerns mainly the histopathological factors. The aim of the study was recognition of prognostic factors in oligodendroglioma. Methods: In a series of nine ty-eight oligodendrogliomas, including twenty mixed oligoastrocytomas, clinical [sex, age at surgery, tumor location, symptoms at presentati on], therapeutic [extent of resection, year of surgery, post-operative Karnofsky score, post-operative radiotherapy, post-operative chemothe rapy], histological [cell density, nuclear pleomorphism, vascular endo thelial proliferation, necrosis, microcysts, mitoses, mitotic index (M I), apoptosis, apoptotic index (AI)] and immunohistochemical parameter s [MIB-1 and PCNA Labeling Indexes (LIs), staining for GFAP, positivit y for p53] were correlated with survival in uni-and multivariate analy sis in order to identify their prognostic significance. Results: Age a t surgery, extent of surgical resection, year of surgery, post operati ve Karnofsky score and MIB-1 LI were associated with survival in both uni-and multivariate analysis. Location, symptoms at presentation, mit oses, MI, AI, and PCNA LI showed a significant correlation with surviv al in uni-but not in multivariate analysis. The twenty cases of oligoa strocytomas did not show any difference in survival from pure oligoden drogliomas. Conclusions: Some clinical and therapeutic factors togethe r with MIB-1 LI play a prognostic role. MIB-1 LI is prognostic with a cut off of 8%. Histology gives a limited contribution to the prognosis . Oligoastrocytomas had the same outcome and prognostic factors as pur e oligodendrogliomas.