SUCCESSFUL TREATMENT OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY WITH LOW-DOSE INTERLEUKIN-2

Authors
PRZEPIORKA D JAECKLE KA BIRDWELL RR FULLER GN KUMAR AJ HUH YO MCCUTCHEON I
Citation
D. Przepiorka et al., SUCCESSFUL TREATMENT OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY WITH LOW-DOSE INTERLEUKIN-2, Bone marrow transplantation, 20(11), 1997, pp. 983-987
Citations number
11
Journal title
Bone marrow transplantation → ACNP
ISSN journal
02683369
Volume
20
Issue
11
Year of publication
1997
Pages
983 - 987
Database
ISI
SICI code
0268-3369(1997)20:11<983:STOPML>2.0.ZU;2-C
Abstract
A patient with low-grade lymphoma presented 8 months after autologous marrow transplantation with dizziness, aphasia and hemiparesis. Magnet ic resonance imaging (MRI) showed an abnormal T2 signal in the frontop arietal region unilaterally. Biopsy of the area demonstrated progressi ve multifocal leukoencephalopathy positive for JC virus and p53. Treat ment with interleukin-2 at 0.5 MU/m(2)/day i.v. continuous infusion re sulted in near complete resolution of symptoms and MRI abnormalities. The absolute number of CD3(+)CD4(+) and CD3(-)CD56(+) cells in the per ipheral blood also increased, and the CD4/CD8 ratio normalized. She re mains free of evidence of progressive multifocal leukoencephalopathy 1 year off therapy.