INHALED VANCOMYCIN-INDUCED ALLERGIC REACTION IN DECONTAMINATION OF RESPIRATORY TRACTS FOR ALLOGENEIC BONE-MARROW TRANSPLANTATION

A 34-year-old male suffered from an allergic reaction after inhalation of decontaminating drugs for BMT. Clinical challenge tests were under taken to determine the causal drug. It was found that vancomycin hydro chloride (VCM) repeatedly induced dyspnea, fever, hypoxia, eosinophili a, and elevation of CRP. Therefore, clindamycin (CLDM) was used instea d of VCM for decontamination of patient respiratory tract. Although co mplete decontamination of the respiratory tract was not achieved durin g the leukocytopenic period, BMT was successful, and there were no lif e-threatening infectious complications. Although inhaled VCM-induced a llergic reaction mag be a very rare complication in the BMT setting, c areful clinical attention should be paid to such patients.