Nk. Terrett et al., DRUG DISCOVERY BY COMBINATORIAL CHEMISTRY - THE DEVELOPMENT OF A NOVEL METHOD FOR THE RAPID SYNTHESIS OF SINGLE COMPOUNDS, Chemistry, 3(12), 1997, pp. 1917-1920
Through the advantages conferred in the speed of synthesis, combinator
ial chemistry is making a significant impact on the process of drug di
scovery. The mix-and-split paradigm has been an effective method for t
he production of compound mixtures, although there is now a need for n
ew, fast library approaches to generate well-characterised single comp
ounds. Having already demonstrated the successful preparation and appl
ication of library mixtures, we have now developed a novel combinatori
al method for the production of single compounds.