A cost-conscious evaluation of CAP in the adult patient requires an in
itial assessment of the clinical severity and the risks of complicated
pneumonia. Initially, most patients should have chest radiography; so
me authorities also recommend sputum Gram staining and culture, but ad
ditional blood testing, culture, and diagnostic procedures are indicat
ed only for patients who have chronically impaired health or clinical
evidence of severe infection. Initial empirical antibiotic therapy var
ies depending on the setting (outpatient, hospitalized patient, critic
ally ill patient). Failure of the patient to respond to empirical anti
biotic therapy within 72 hours should direct the clinician to consider
unusual or resistant organisms or noninfectious causes of pneumonitis
.