DIFFERENTIAL CONTRIBUTION OF GRAFT AND RECIPIENT TO PERIOPERATIVE TNF-ALPHA, IL-1-BETA, IL-6 AND IL-8 LEVELS AND CORRELATION WITH EARLY GRAFT FUNCTION IN CLINICAL LIVER-TRANSPLANTATION
P. Boros et al., DIFFERENTIAL CONTRIBUTION OF GRAFT AND RECIPIENT TO PERIOPERATIVE TNF-ALPHA, IL-1-BETA, IL-6 AND IL-8 LEVELS AND CORRELATION WITH EARLY GRAFT FUNCTION IN CLINICAL LIVER-TRANSPLANTATION, Clinical transplantation, 11(6), 1997, pp. 588-592
Cytokines, produced by both the recipient and the newly vascularized a
llograft, are central mediators in the inflammatory response to allogr
afted tissue. This study examines the relationship between pre-and int
raoperative levels of TNF IL-1, IL-6, and IL-8 and hepatic allograft f
unction in the early postoperative period and also determines which cy
tokines are produced in a significant amount by the newly vascularized
allograft. Baseline levels of IL-6 and IL-8 tended to be higher in pa
tients with more advanced disease and showed an increase during the an
hepatic period. TNF and IL-1 remained stable from baseline to anhepati
c phase. IL-1 showed an increase from portal vein to effluent samples,
suggesting that the graft has an important contribution to circulatin
g IL-1 levels. Analysis of the data according to early graft performan
ce revealed extremely high levels of effluent IL-1, IL-6 and IL-8, and
the prolonged elevation of the latter two cytokines in patients with
poor early graft function. Our findings demonstrate that sequential pe
rioperative measurements of proinflammatory cytokines can be useful in
monitoring graft function.