EFFECT OF PERCUTANEOUS-ABSORPTION OF FLUOCINOLONE ACETONIDE ON THE ACTIVITY OF SUPEROXIDE-DISMUTASE AND TOTAL ANTIOXIDANT STATUS IN PATIENTS WITH PSORIASIS

This study defines a modification of antioxidant systems by percutaneo us absorption of fluocinolone acetonide, Total antioxidant status (TAS ) provides an overall indication of antioxidant status, Superoxide dis mutase (SOD), a primary antioxidant, accelerates the dismutation of th e toxic superoxide radical produced during the oxidative energy proces ses into the less harmful molecules, hydrogen peroxide and molecular o xygen, We monitored the level of SOD and TAS in 7 males with psoriasis and 6 control subjects before and after a single application of fluoc inolone acetonide 0.025% ointment to 90% of the body. The results show ed that the plasma level of TAS was significantly increased (p < 0.02) at 24 h posttreatment, The erythrocytic level of SOD was significantl y decreased (p < 0.01) only at 12 h after glucocorticosteroid applicat ion, The level of TAS and SOD in patients with psoriasis was also sign ificantly increased (p < 0.01 for both situations) as compared to heal thy controls. Our study suggests that fluocinolone acetonide as a ther apeutic agent may play a role in the oxidative stress in skin diseases .