EFFECT OF ALUMINUM ADMINISTRATION IN CHRONIC-RENAL-FAILURE

We have evaluated modifications of Al serum values (Al-s) and Al urina ry levels (Al-u) in 10 healthy controls (C) and 10 subjects on moderat e chronic renal failure (CRF), at times 0, 1, 2, 3, 4, 8, 12, 16, 24 h ours after the oral administration of a dose of 2 g Al (as Al hydroxid e). In C, Al absorption is rapid with peak serum levels occurring 1 - 2 hours after administration and normal values of Al-s returning to th e rule after the 4th hour. The absorption is prolonged in CRF and Al-s presents increased levels for all 24 hours. In C, aluminum clearance (Cl-Al) shows a peak excretion contemporaneously to Al-s increased, re turning to the rule after the 4th hour. In CRF, instead, Cl-Al begins decreasing after the 8th hour and it returns to basal values after the 12th hour, In C, the urinary excretion of Al (Al-u) shows a rapid inc rease just from the 1st hour after Al-hy, until values about 20 times higher to the 4th hour and returning to the rule after the 12th hour. In CRF, indeed, timed Al-u shows lower increases (only 1,5 times) afte r the 12th hour. Al-s variation (from basal values) vs, Al-u variation shows positive correlation in C, but negative in CRF, The data confir m our previous experiences [1994, 1995, 1996]: in the moderate CRF, to o, the exposure to Al gives a tissue accumulation of it.