RELATIVE ABUNDANCE OF SOME FREE FATTY-ACIDS IN PLASMA OF UREMIC PATIENTS - RELATIONSHIP BETWEEN FATTY-ACIDS, LIPID PARAMETERS, AND DISEASES

The unesterified fatty acid patterns in plasma of predialytic (PHD) an d hemodialysis (HD) patients were determined. The HD patients were div ided three groups: (1) HD without cardiovascular disease (HD-norm); (2 ) HD with cardiomyopathy (HD-CAD), and (3) HD with hyperlipidemia (HD- hyp). The relative abundance of saturated fatty acids (SFAs) was great er in the plasma of HD-norm and HD-CAD patients (73.3 and 70.0%, respe ctively) than that in controls (62.6%), and the relative abundance of monounsaturated fatty acids (MUFAs) was significantly greater in the p lasma of HD-hyp patients than that in controls (38.9 vs. 21.6%, p < 0. 01). In all HD patients the relative concentration of polyunsaturated fatty acids (PUFAs) was lower than in controls. There were no signific ant differences in the fatty acid patterns of PHD patients. In conclus ion, the relative abundance of SFAs and MUFAs in plasma of HD patients is associated with their concomitant lipid disorders and cardiomyopat hy, while the low relative abundance of PUFAs was common in all HD pat ients.