INTERACTION OF MUTAGENIC TRYPTOPHAN PYROLYSATE WITH D(CGATCG)(2) - INTERCALATION MODEL-BASED ON NMR EXPERIMENTS

Authors
MIHARA Y DOI M INOHARA T KAWAMURA M HAMANAKA N ISHIDA T
Citation
Y. Mihara et al., INTERACTION OF MUTAGENIC TRYPTOPHAN PYROLYSATE WITH D(CGATCG)(2) - INTERCALATION MODEL-BASED ON NMR EXPERIMENTS, Biochemical and biophysical research communications, 240(3), 1997, pp. 803-806
Citations number
15
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
240
Issue
3
Year of publication
1997
Pages
803 - 806
Database
ISI
SICI code
0006-291X(1997)240:3<803:IOMTPW>2.0.ZU;2-J
Abstract
The solution structure of the complex of 3-amino-1 ,4-dimethyl-5H-pyri do[4,3-b]indole (Trp-P-1), a potent mutacarcinogen isolated from trypt ophan pyrolysate, with the hexamer duplex d(CGATCG)(2), was analysed b y H-1-NMR spectroscopy and molecular dynamic calculation. Trp-P-1 was intercalated between the CpG base pairings in a suitable manner to for m the guanosine-Trp-P-1 adduct which corresponds to the major reactant of Trp-P-1 with DNA. (C) 1997 Academic Press.