EFFECTS OF FLUNARIZINE AND NITRENDIPINE ON ELECTROCONVULSIVE SHOCK-INDUCED AND CLONIDINE-INDUCED AMNESIA

Authors
GENKOVAPAPAZOVA M PETKOVA BP LAZAROVABAKAROVA M BOYANOVA E STANEVASTOYTCHEVA D
Citation
M. Genkovapapazova et al., EFFECTS OF FLUNARIZINE AND NITRENDIPINE ON ELECTROCONVULSIVE SHOCK-INDUCED AND CLONIDINE-INDUCED AMNESIA, Pharmacology, biochemistry and behavior, 56(4), 1997, pp. 583-587
Citations number
48
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Pharmacology, biochemistry and behavior → ACNP
ISSN journal
00913057
Volume
56
Issue
4
Year of publication
1997
Pages
583 - 587
Database
ISI
SICI code
0091-3057(1997)56:4<583:EOFANO>2.0.ZU;2-E
Abstract
This study was designed to examine the calcium channel blockers flunar izine and nitrendipine for their ability to prevent electroconvulsive shock (ECS)- or clonidine-induced deterioration of the inhibitory avoi dance performance (step-down) in rats. Flunarizine (10 mg/kg) and nitr endipine (40 mg/kg) were found to prevent the ECS- or clonidine-provok ed amnesia after oral administration for 12 days. The mechanisms of ac tion of the two drugs are considered. The results of this study furthe r suggest that calcium antagonists might be useful in the treatment of cognitive disorders. (C) 1997 Elsevier Science Inc.