INDOMETHACIN NORMALIZES INTRACRANIAL-PRESSURE IN ACUTE LIVER-FAILURE - A 23-YEAR-OLD WOMAN TREATED WITH INDOMETHACIN

In patients with acute liver failure, cerebral herniation is a common cause of death. The present study reports the effect of indomethacin o n four occasions of intracranial hypertension, in a 23-year old previo usly healthy woman with severe acetaminophen poisoning. During each ep isode of intracranial hypertension, the patient was treated with 25 mg of indomethacin, and each time the intracranial pressure normalized. We recommend further controlled studies to determine the exact effect of indomethacin on cerebral blood flow and metabolism before it is rec ommended for treatment of intracranial hypertension in patients with a cute liver failure.