ALGINATE PRODUCTION BY AZOTOBACTER-VINELANDII

Although all commercial alginates are today of algal origin, there is interest in the production of alginate-like polymers from bacteria. Th e species Azotobacter vinelandii seems to be the best candidate for th e industrial production of alginate molecules characterized by a chemi cal composition, molecular mass and molecular mass distribution suited to a well defined application, especially required in the biotechnolo gical, biomedical and pharmaceutical fields. The production of alginat e by A. vinelandii has been to date widely investigated both in batch (mainly in the shaken flask scale) and in continuous cultures. This ar ticle summarizes current knowledge on the structure and properties of alginates and their applications and presents an overview of up-dated research on the physiology, genetics and kinetics of the production of alginate by Azotobacter vinelandii and its rheology, including the re sults of our recent studies.