EFFECTS OF TRAINING AND A SINGLE SESSION OF EXERCISE ON LIPIDS AND APOLIPOPROTEINS IN HYPERCHOLESTEROLEMIC MEN

To differentiate between transient (acute) and training (chronic) effe cts of exercise at two different intensities on blood Lipids and apoli poproteins (ape), 26 hypercholesterolemic men (cholesterol = 258 mg/dl , age = 47 yr, weight = 81.9 kg) trained three times per week for 24 w k, 350 kcal/session at high (80% maximal O-2 uptake, n = 12) or modera te (50% maximal O-2 uptake, n = 14) intensity. Serum lipid and apolipo protein (ape) concentrations (plasma volume adjusted) were measured be fore and immediately, 24, and 48 h after exercise on four different oc casions corresponding to 0, 8, 16, and 24 wk of training. Data were an alyzed using three-way repeated measures multivariate analysis of vari ance followed by analysis of variance and Duncan's procedures (alpha = 0.05). A transient 6% rise in low-density-lipoprotein cholesterol mea sured before training at the 24-h time point was no longer evident aft er training. Triglycerides fell and total cholesterol, high-density-li poprotein cholesterol (HDL-C), HDL3-C, apo A-I, and apo B rose 24-48 h after exercise regardless of training or intensity. Total cholesterol , HDL3-C, apo A-I, and apo B were lower and HDL2-C was higher after tr aining than before training. Thus exercise training and a single sessi on of exercise exert distinct and interactive effects on lipids and ap olipoproteins. These results support the practice of training at least every other day to obtain optimal exercise benefits.