ANTIMETASTATIC ACTIVITY OF THE NEW PLATINUM ANALOG (PT(CIS-DACH)(DPPE)CENTER-DOT-2NO(3)) IN A METASTATIC MODEL OF HUMAN BLADDER-CANCER

Surgical orthotopic implantation (SOI) of histologically intact human RT-4 bladder tumor tissue in nude mice resulted in local growth, invas ion regional extension and metastases as well as distant metastases to other organ sites and lymph nodes, thus mimicking the bladder cancer patient. This metastatic bladder tumor animal model was treated with t wo doses of new platinum analog {Pt(cis-dach)(DPPE). 2NO(3)} for the e valuation of antimetastatic efficacy compared to two doses of cisplati num. Unlike the untreated control group or the group treated with the low dose of cisplatinum, there were no metastases in either the high o r-low-dose platinum-analog-treated groups and the high-dose cisplatinu m-treated group. The results obtained with this patient-like nude-mous e model of bladder cancer indicate that the new platinum analog appear s to be a valuable lead compound with antimetastatic efficacy and clin ical potential.