CISPLATIN AND MILD HYPERTHERMIA IN RADIOSENSITIZATION TO LOW-DOSE RATE IRRADIATION IN HUMAN OVARIAN-CARCINOMA CELLS

Two human ovarian carcinoma cell lines, one parental and the other a c isplatin resistant derivative cell line, were evaluated for the effica cy of combined treatments of mild hyperthermia, cisplatin and low dose rate irradiation (LDRI). The data showed that cisplatin (1 or 3 mu g/ ml for 1 hour) combined with mild hyperthermia (40 degrees C for I hou r) was effective far radiosensitization to LDRI in the parental cell l ine whether given before or after irradiation. In the cisplatin resist ant variant, however, these treatments had little to no effect on LDRI response. Thus these data show that these treatments could be clinica lly effective if there is no cisplatin resistance. Our previous study showed that concomitant treatments could be effective in both parental and cisplatin resistant cell line (1).