COMUTAGENESIS-I - THE IN-VITRO METABOLISM OF 2-AMINO-3-METHYLPYDIDINE

The metabolism of the comutagen 2-amino-3-methylpyridine has been stud ied in vitro using rat and rabbit hepatic preparations. 2-Amino-3-meth ylpyridine-N-oxide, 2-amino-3-hydroxymethylpyrdine and 2-amino-5-hydro xy-3-methylpyridine were formed by both rat and rabbit hepatic prepara tions. No evidence was obtained for the formation of the corresponding 2-hydroxylamine, 2-nitroso, 2-nitro-3-methylpyridine or their condens ation products i.e. ate, azoxy or hydrate. The results are discussed i n relation to the possible mechanism of action of the substrate.