REDUCTIVE AMINATION WITH ZINC BOROHYDRIDE - EFFICIENT, SAFE ROUTE TO FLUORINATED BENZYLAMINES

Authors
BHATTACHARYYA S CHATTERJEE A WILLIAMSON JS
Citation
S. Bhattacharyya et al., REDUCTIVE AMINATION WITH ZINC BOROHYDRIDE - EFFICIENT, SAFE ROUTE TO FLUORINATED BENZYLAMINES, Synthetic communications, 27(24), 1997, pp. 4265-4274
Citations number
68
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
27
Issue
24
Year of publication
1997
Pages
4265 - 4274
Database
ISI
SICI code
0039-7911(1997)27:24<4265:RAWZB->2.0.ZU;2-8
Abstract
Fluorinated benzylamines are synthesized in high yields by reductive a lkylation of secondary amines with appropriate fluoroaldehydes using a combination of zinc chloride and zinc borohydride. The present method offers an alternative to toxic sodium cyanoborohydride and is adaptab le to multigram-scale preparations.