SYNTHESIS OF HIV-1 REVERSE-TRANSCRIPTASE INHIBITOR DMP-266

Authors
RADESCA LA LO YS MOORE JR PIERCE ME
Citation
La. Radesca et al., SYNTHESIS OF HIV-1 REVERSE-TRANSCRIPTASE INHIBITOR DMP-266, Synthetic communications, 27(24), 1997, pp. 4373-4384
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
27
Issue
24
Year of publication
1997
Pages
4373 - 4384
Database
ISI
SICI code
0039-7911(1997)27:24<4373:SOHRID>2.0.ZU;2-R
Abstract
DMP 266, a potent non-nucleoside HIV-1 reverse transcriptase inhibitor was prepared in six steps starting from commercially available 4-chlo rophenyl isocyanate. The racemic compound was formed very efficiently from N-tert-butoxycarbonyl-4-chloroaniline and resolution was accompli shed via the (-)-camphanates.