MALIGNANT TRANSFORMATION IN OLLIERS DISEA SE - A CASE-REPORT

Malignant transformation of multiple chondromas observed in Oilier's d isease is a well known possibility. In the clinical case of a 52 year old woman reported here, the sarcomatous transformation of two endocho ndromatous foci occured successively in less than one year. One was lo cated in the calcaneus, the other within the proximal metaphysis of th e ipsilateral fibula. This case is worth reporting for two reasons: - the successive occurrence of these sarcomatous lesions led to a amputa tion below the knee, later completed by an extended radical resection of the fibula, This combination allowed to preserve the knee with a go od functional result and without local recurrence, - this clinical cas e may be compared with that reported by Goodman in 1984. Both cases sh ow that sarcomatous transformations may occur almost simultaneously af ter a long quiscent period and suggest the existence of a factor that could trigger or favor a malignant transformation process.