F. Dujardin et al., MALIGNANT TRANSFORMATION IN OLLIERS DISEA SE - A CASE-REPORT, Revue de chirurgie orthopedique et reparatrice de l'appareil moteur, 83(2), 1997, pp. 160-163
Malignant transformation of multiple chondromas observed in Oilier's d
isease is a well known possibility. In the clinical case of a 52 year
old woman reported here, the sarcomatous transformation of two endocho
ndromatous foci occured successively in less than one year. One was lo
cated in the calcaneus, the other within the proximal metaphysis of th
e ipsilateral fibula. This case is worth reporting for two reasons: -
the successive occurrence of these sarcomatous lesions led to a amputa
tion below the knee, later completed by an extended radical resection
of the fibula, This combination allowed to preserve the knee with a go
od functional result and without local recurrence, - this clinical cas
e may be compared with that reported by Goodman in 1984. Both cases sh
ow that sarcomatous transformations may occur almost simultaneously af
ter a long quiscent period and suggest the existence of a factor that
could trigger or favor a malignant transformation process.