A NEW PHOSPHORAMIDITE REAGENT FOR THE INCORPORATION OF DIAZAPHENOXAZINONE NUCLEOSIDE WITH ENHANCED BASE-PAIRING PROPERTIES INTO OLIGODEOXYNUCLEOTIDES

Authors
KURCHAVOV NA STETSENKO DA SKAPTSOVA NV POTAPOV VK SVERDLOV ED
Citation
Na. Kurchavov et al., A NEW PHOSPHORAMIDITE REAGENT FOR THE INCORPORATION OF DIAZAPHENOXAZINONE NUCLEOSIDE WITH ENHANCED BASE-PAIRING PROPERTIES INTO OLIGODEOXYNUCLEOTIDES, Nucleosides & nucleotides, 16(10-11), 1997, pp. 1837-1846
Citations number
21
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
10-11
Year of publication
1997
Pages
1837 - 1846
Database
ISI
SICI code
0732-8311(1997)16:10-11<1837:ANPRFT>2.0.ZU;2-B
Abstract
New phosphoramidite reagent 7 suitable for incorporation of dC analogu e was synthesized. ODNs containing diazaphenoxazinone residues in defi ned positions were prepared. The stability of duplexes formed was incr eased up to 3-5 degrees C per modified base. Preliminary results of mo lecular biological testing were reported.