A. Farese et al., LIQUID-PHASE SYNTHESIS OF PEPTIDE NUCLEIC-ACID (OR POLYAMIDE NUCLEIC-ACID) DIMERS, Nucleosides & nucleotides, 16(10-11), 1997, pp. 1893-1906
The liquid phase synthesis of ''polyamide nucleic acid'' (PNA) dimers
containing the purine nucleic acid bases adenine and guanine has been
achieved in good yields. This strategy was elaborated in order to circ
umvent difficult direct coupling of protected PNA monomers. This metho
d can be applied to the liquid phase synthesis of short protected poly
PNAs fragments, which can then selectively be deprotected.