NEUROPEPTIDE-Y RECEPTOR GENES MAPPED IN HUMAN AND MOUSE - RECEPTORS WITH HIGH-AFFINITY FOR PANCREATIC-POLYPEPTIDE ARE NOT CLUSTERED WITH RECEPTORS SPECIFIC FOR NEUROPEPTIDE-Y AND PEPTIDE YY

Ppyr1, Npy5r, and Npy6r, the genes encoding mouse type 4, type 5, and type 6 members of the neuropeptide Y receptor family, have been mapped by interspecific backcross analysis to conserved linkage groups on mo use Chr 14, Chr 8, and Chr 18, respectively, The human genes, PPYR1 an d NPY5R, have been localized to chromosomes 10q and 4q, respectively, by analysis of a panel of rodent-human somatic cell hybrids and yeast artificial chromosomes. These studies complete the mapping of the clon ed NPY receptor subtypes in human and mouse and, together with previou s studies, establish that the genes encoding receptors with high affin ity for pancreatic polypeptide are not clustered with the genes encodi ng receptors specific for neuropeptide Y and peptide YY. The physical association of these receptor genes correlates with ligand-binding pro perties, rather than sequence identity, and suggests a complex evoluti onary relationship. (C) 1997 Academic Press.