CLINICAL AND MOLECULAR PATHOLOGY OF AGGRESSIVE SCHNEIDERIAN PAPILLOMAINVOLVING THE TEMPORAL BONE

Background. Inverting papilloma is a benign but locally aggressive sin onasal tumor that rarely involves the middle ear or temporal bone. Met hods. A report of a case and the molecular pathology of the tumor is p resented. Results. A 35-year-old woman with a history of recurrent inv erting papilloma of the left paranasal sinuses was found to have evide nce of extension through the eustachian tube and extensive involvement of the temporal bone. Surgical management resulted in the patient bei ng disease-free at 14 months. Molecular pathology studies of the resec ted tumor suggest an association with human papillomavirus. Conclusion s. Direct extension of the sinonasal tumor through the eustachian tube may represent the pathologic mechanism involved in the development of inverting papilloma involving the middle ear and temporal bone. (C) 1 998 John Wiley & Sons, Inc.