THE MURINE CAR HOMOLOG IS A RECEPTOR FOR COXSACKIE-B VIRUSES AND ADENOVIRUSES

Complementary DNA clones encoding the murine homolog (mCAR) of the hum an coxsackievirus and adenovirus receptor (CAR) were isolated. Nonperm issive CHO cells transfected with mCAR cDNA became susceptible to infe ction by coxsackieviruses B3 and B4 and showed increased susceptibilit y to adenovirus-mediated gene transfer. These results indicate that th e same receptor is responsible for virus interactions with both murine and human cells. Analysis of receptor expression in human and murine tissues should be useful in defining factors governing virus tropism i n vivo.