MINIMAL REQUIREMENT FOR A LENTIVIRUS VECTOR BASED ON HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1

Authors
KIM VN MITROPHANOUS K KINGSMAN SM KINGSMAN AJ
Citation
Vn. Kim et al., MINIMAL REQUIREMENT FOR A LENTIVIRUS VECTOR BASED ON HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1, Journal of virology, 72(1), 1998, pp. 811-816
Citations number
61
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
72
Issue
1
Year of publication
1998
Pages
811 - 816
Database
ISI
SICI code
0022-538X(1998)72:1<811:MRFALV>2.0.ZU;2-U
Abstract
The use of human immunodeficiency virus vectors for gene therapy is ha mpered by concern over their safety. This concern might be ameliorated , in part, if the viral accessory genes and proteins could be eliminat ed from the vector genomes and particles. Here we describe a minimal v ector system that is capable of transducing nondividing cells and whic h does not contain tat, vif, vpr, vpu, and nef.