HEPATITIS-G VIRUS ENCODES PROTEASE ACTIVITIES WHICH CAN EFFECT PROCESSING OF THE VIRUS PUTATIVE NONSTRUCTURAL PROTEINS

Authors
BELYAEV AS CHONG S NOVIKOV A KONGPACHITH A MASIARZ FR LIM M KIM JP
Citation
As. Belyaev et al., HEPATITIS-G VIRUS ENCODES PROTEASE ACTIVITIES WHICH CAN EFFECT PROCESSING OF THE VIRUS PUTATIVE NONSTRUCTURAL PROTEINS, Journal of virology, 72(1), 1998, pp. 868-872
Citations number
34
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
72
Issue
1
Year of publication
1998
Pages
868 - 872
Database
ISI
SICI code
0022-538X(1998)72:1<868:HVEPAW>2.0.ZU;2-2
Abstract
The genome of a recently identified virus, hepatitis G virus (HGV), sh ows considerable homology to hepatitis C virus (HCV). Two HGV protease s similar to nonstructural proteins NS2 and NS3 of HCV were identified , and their cleavage site specificity was investigated. Amino acids es sential for the protease activities were determined by mutation analys is. NS4A of HGV was demonstrated to be a cofactor for NS3-mediated pro teolysis, with a region critical for activity residing between Leu(156 1) and Ala(1598).