PROMOTION OF THE FORMATION OF PHENYLALANINE-THYMINE CROSS-LINKED PRODUCTS BY FREE-RADICALS FORMED DURING CARBON-TETRACHLORIDE ACTIVATION WITH BENZOYL PEROXIDE IN MODEL SYSTEMS - A MASS-SPECTROMETRIC STRUCTURALSTUDY

Authors
CASTRO GD CASTRO JA
Citation
Gd. Castro et Ja. Castro, PROMOTION OF THE FORMATION OF PHENYLALANINE-THYMINE CROSS-LINKED PRODUCTS BY FREE-RADICALS FORMED DURING CARBON-TETRACHLORIDE ACTIVATION WITH BENZOYL PEROXIDE IN MODEL SYSTEMS - A MASS-SPECTROMETRIC STRUCTURALSTUDY, Research communications in molecular pathology and pharmacology, 98(1), 1997, pp. 85-90
Citations number
13
Journal title
Research communications in molecular pathology and pharmacology → ACNP
ISSN journal
10780297
Volume
98
Issue
1
Year of publication
1997
Pages
85 - 90
Database
ISI
SICI code
1078-0297(1997)98:1<85:POTFOP>2.0.ZU;2-L
Abstract
Reaction mixtures containing phenylalanine methyl ester and thymine in pure carbon tetrachloride in the presence of benzoyl peroxide produce d trichloromethyl and trichloromethylperoxyl free radicals which via h ydrogen abstraction reactions sparked the formation of phenylalanine-t hymine adducts, whose structures were elucidated by mass spectrometry. If similar type of reaction occurred under biological conditions, sig nificant deleterious consequences might be anticipated.