NEUTROPHIL ELASTASE INHIBITOR (ONO-5046-CENTER-DOT-NA) SUPPRESSES THEPROLIFERATION, MOTILITY AND CHEMOTAXIS OF A PANCREATIC-CARCINOMA CELL-LINE, CAPAN-1

Authors
KAMOHARA H SAKAMOTO K MITA S AN XY OGAWA M
Citation
H. Kamohara et al., NEUTROPHIL ELASTASE INHIBITOR (ONO-5046-CENTER-DOT-NA) SUPPRESSES THEPROLIFERATION, MOTILITY AND CHEMOTAXIS OF A PANCREATIC-CARCINOMA CELL-LINE, CAPAN-1, Research communications in molecular pathology and pharmacology, 98(1), 1997, pp. 103-108
Citations number
13
Journal title
Research communications in molecular pathology and pharmacology → ACNP
ISSN journal
10780297
Volume
98
Issue
1
Year of publication
1997
Pages
103 - 108
Database
ISI
SICI code
1078-0297(1997)98:1<103:NEI(ST>2.0.ZU;2-0
Abstract
ONO-5046 . Na is a specific neutrophil elastase inhibitor. We investig ated the in vitro effect of ONO-5046 . Na on the proliferation, motili ty and chemotaxis of a pancreatic carcinoma cell line (Capan-1, well d ifferentiated adenocarcinoma). ONO-5046 . Na significantly suppressed the proliferation, motility and chemotaxis at a concentration of more than 100, 10 and 1 mu g/ml of ONO-5040 . Na, respectively (p < 0.005, p < 0.05 and p < 0.05, respectively). These results indicate that ONO- 5046 . Na may have a role in preventing the progression and metastasis of pancreatic carcinoma cells, suggesting that ONO-5046 . Na may serv e as an anti-cancer agent.