TRIPLE CHECK FOR ANTIGEN-SPECIFICITY OF B-CELLS DURING GERMINAL CENTER REACTIONS

Authors
LINDHOUT E KOOPMAN G PALS ST DEGROOT C
Citation
E. Lindhout et al., TRIPLE CHECK FOR ANTIGEN-SPECIFICITY OF B-CELLS DURING GERMINAL CENTER REACTIONS, Immunology today, 18(12), 1997, pp. 573-577
Citations number
35
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
18
Issue
12
Year of publication
1997
Pages
573 - 577
Database
ISI
SICI code
0167-5699(1997)18:12<573:TCFAOB>2.0.ZU;2-4
Abstract
Somatic hypermutation of the immunoglobulin variable genes during germ inal reactions might permit the expansion of B-cell clones with unwant ed (e.g. autoreactive) specificity. Here, Ernst Lindhout and colleague s propose three antigen-specific checkpoints that ensure the appropria te antigen specificity of activated B cells is maintained by regulatin g the activation, selection and further differentiation of B cells.