FCRN - THE MHC CLASS I-RELATED RECEPTOR THAT IS MORE THAN AN IGG TRANSPORTER

Authors
GHETIE V WARD ES
Citation
V. Ghetie et Es. Ward, FCRN - THE MHC CLASS I-RELATED RECEPTOR THAT IS MORE THAN AN IGG TRANSPORTER, Immunology today, 18(12), 1997, pp. 592-598
Citations number
49
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
18
Issue
12
Year of publication
1997
Pages
592 - 598
Database
ISI
SICI code
0167-5699(1997)18:12<592:F-TMCI>2.0.ZU;2-U
Abstract
Recent data have indicated that the major histocompatibility complex ( MHC) class I-related receptor FcRn plays a role in regulating serum Ig G levels, in addition to transferring maternal IgGs across the rodent neonatal gut. The isolation of a human homolog of FcRn from placenta s uggests that the studies in rodents have relevance to understanding si milar processes in humans. This has implications for the engineering o f improved antibodies for therapy.