Background and Objectives. Genitofemoral nerve (GFN) block is a known
side effect of a lumbar sympathetic block (LSB), although the incidenc
e has not been well documented. Furthermore, genitofemoral neuralgia c
an occur following neurolytic LSB (1). Because the level at which the
GFN exits the psoas sheath varies, this study was designed to identify
differences in the incidence of GFN block following LSB at the level
of the second versus the fourth lumbar vertebrae. Methods. Patients re
quiring LSB to evaluate chronic lower extremity pain were prospectivel
y studied. Patients were injected at the second lumbar (L2 group) or f
ourth lumbar (L4 group) vertebral body depending on the location of th
e pain syndrome in the lower extremity. Lumbar sympathetic blocks were
performed using 10 mL of a 0.5% bupivacaine solution with radiocontra
st; spread of injectate was verified using fluoroscopy. An observer ev
aluating for presence of GFN block was blinded to the lumbar level of
injection. Results. Thirty patients were enrolled (L2 group, n = 15; L
4 group, n = 15). Spread of local anesthetic/radiocontrast solution wa
s limited to approximately one vertebral body above and one below the
target level. There was no difference in the ability to achieve a LSB;
success rates were 66% and 73% using L2 and L4, respectively. The inc
idence of GFN block was 0% (0/15) in the L2 group versus 40% (6/15) in
the L4 group; this was statistically significant (P = .017, Fisher's
exact test). Conclusions. The GFN is less likely to be blocked when th
e LSB is performed near the second lumbar vertebra as compared with th
e fourth lumbar vertebra.