Oral anti-coagulation with warfarin is increasingly required in the pr
ophylaxis and treatment of vascular thrombosis and embolism, Unless th
e degree of anti-coagulation is maintained in the narrow therapeutic r
ange either serious bleeding or failure to prevent thromboembolism may
occur, Complications may occur in up to 31% of patients, We randomly
sampled 50 patients attending an anticoagulant clinic and interviewed
them, We found the PTR between 2.0-4.0 in 70% patients, Their records
indicated that they attended 0.9+/-0.5 times per month, but the patien
ts themselves said that they had 2.4+/-1.7 visits per month, lasting o
n average 1.9+/-0.7 hours per visit, The mean duration of therapy was
4.3+/-5.4 Sears [range 1 month to 26 years], il Many patients perceive
d that they had received no education about warfarin (23%) while the m
ajority 67% of the remainder said their doctor had educated them, Conc
omitant aspirin was avoided by 74% patients but 14% considered it safe
in combination with warfarin; 49% patients believed that alcohol was
safe in combination with warfarin, When asked about the colours and st
rengths of warfarin tablets, 37% of our sample were completely correct
, 9% were completely incorrect and 54% were partly correct, In 16% pat
ients they could not describe their current therapy, As doctors may ad
just warfarin dosage for patients in terms of tablet colour, we asked
a sample of junior doctors about the colours or strengths of warfarin
tablets: 10% were completely correct, one doctor knew none of the colo
urs or strengths and the remainder had a partial knowledge. These stud
ies suggest that the majority of patients on warfarin are cautious abo
ut therapy and are safe in their practices, However, we feel that a si
gnificant minority may be at risk from complications because of inadeq
uate knowledge. We suggest that improving patient understanding by edu
cation may reduce complications and lead to more stable control of ant
icoagulant therapy.