APPLICATIONS OF SITE-SPECIFIC CHEMICAL MODIFICATION IN THE MANUFACTURE OF BIOPHARMACEUTICALS .1. AN OVERVIEW

The chemical modification of proteins has long been a useful approach to elucidating structure-function relationships, Recently, these same chemistries have beers finding application in the preparation of prote ins for both diagnostic and therapeutic use. These applications includ e alterations to introduce new properties, such as improved stability, or new traits, such as drug binding and transport, that take advantag e of both broad and narrow ranges of selectivity, Site-specific chemic al modification of proteins, when combined with the powerful advantage s of site-specific mutagenesis, can yield protein agents superior to t hose generated by either approach alone.