Aberrant origin of the light subclavian artery occurs in up to 1% of t
he population and can result in a wide range of symptoms. In this repo
rt, two cases of this anomaly are presented. In the first case, a pati
ent developed fatal group A streptococcal aortitis. In the second case
, the patient complained of chronic cough and intermittent dyspnea. Th
e embryologic genesis of this abnormality is discussed and the current
literature is summarized. Although relatively uncommon, it is importa
nt to consider this vascular anomaly in the differential diagnosis of
patients with dysphagia, dyspnea, chest pain, fever, or mediastinal wi
dening evidenced on chest roentgenography.