ANALYSIS OF FAILURES IN PATIENTS WITH STAGE-I OVARIAN-CANCER - AN ITALIAN MULTICENTER STUDY

The objective of this retrospective multicenter study was to assess th e rates, times, sites, and risk factors for recurrences in 224 patient s with surgical stage I ovarian cancer. Postoperative adjuvant treatme nt was given to 153 of these patients. One hundred and eighty-two (81. 3%) patients are currently alive with no clinical evidence of disease after a median time of 84 months (range, 4-191 months) from surgery, w hereas 39 (17.4%) developed recurrent disease after a median time of 2 9 months (range, 5-112 months). The relapse involved the pelvis in 21 (53.8%) cases, abdomen in 19 (48.7%), pelvic and/or para-aortic lymph nodes in 5 (12.8%), and distant sites in 5 (12.8%). The risk of recurr ence was significantly related to PICO substage (P < 0.0001) and tumor grade (P < 0.0001), but not to histological subtype. However, the rec urrence rate was lower in mucinous carcinomas (6/52, 11.5%) and higher in clear cell carcinomas (5/14, 35.7%). By log-rank test the disease- free survival was significantly related to FIGO substage (P = 0.0006) and grade (P = 0.0001). Cox proportional hazard model showed that grad e was the only independent prognostic variable for disease-free surviv al, with a risk ratio for relapse of 2.831 (95% CI, 1.120-6.624) for g rade 2 and 7.725 (95% CI, 3.290-18.140) for grade 3, compared to grade 1. In conclusion, tumor grade is the strongest predictor of recurrenc e in stage I ovarian cancer.