RELEASE OF TOBRAMYCIN FROM TOBRAMYCIN-CONTAINING BONE-CEMENT IN BONE AND SERUM OF RABBITS

Authors
NIJHOF MW DHERT WJA TILMAN PBJ VERBOUT AJ FLEER A
Citation
Mw. Nijhof et al., RELEASE OF TOBRAMYCIN FROM TOBRAMYCIN-CONTAINING BONE-CEMENT IN BONE AND SERUM OF RABBITS, Journal of materials science. Materials in medicine, 8(12), 1997, pp. 799-802
Citations number
22
Journal title
Journal of materials science. Materials in medicine → ACNP
ISSN journal
09574530
Volume
8
Issue
12
Year of publication
1997
Pages
799 - 802
Database
ISI
SICI code
0957-4530(1997)8:12<799:ROTFTB>2.0.ZU;2-Q
Abstract
Tobramycin release from tobramycin-containing bone cement was studied in vivo in a rabbit model. After insertion of cement into the right fe mur, tobramycin concentration as a function of time for up to 28 days was measured in serum and bone of rabbits. Tobramycin release in the f emoral cortex adjacent to the cement was found to exceed the minimal i nhibitory concentration for Staphylococcus aureus Wood 46. Serum tobra mycin concentrations were below the systemic toxicity threshold.