ADULT-ONSET KRABBES-LEUKODYSTROPHY - A REPORT OF 2 CASES

Krabbe's disease with adult onset is rare; neurological symptoms begin in childhood or at a juvenile age. Two brothers with adult onset of t he disease are here reported; 1 sibling developed parapareto-ataxic ga it while the other was asymptomatic. Magnetic resonance imaging showed areas of demyelination in the white matter of the brain, while nerve conduction was completely normal. In both patients deficiency of galac tosylceramide beta-galactosidase was comparable to the infantile form.